DIC cases were identified by scores greater than or equal to 5 based on the ISTH scoring system independent of clinical manifestations such as bleeding or organ failure. Women with other hematological conditions and women with a total score comprising the platelet count in peripheral blood plus prothrombin time plus fibrinogen level that was greater than or equal to 2 but less than 5 according to the International Society of Thrombosis and Hemostasis scoring system (ISTH) for deficiencies in fibrin/fibrinogen degradation levels were excluded. All three hospitals are academic hospitals with critical maternal care centers.Īll women in any trimester of pregnancy or within 42 days of delivery who were admitted to any of the three ICUs for obstetric reasons for at least 24 h between January 2008 and December 2016 were included. This retrospective cohort study was conducted in the ICUs of three hospitals in Beijing City, China, namely, Peking University Third Hospital, Peking University First Hospital, and Capital Medical University Affiliated Beijing Chao-Yang Hospital. The control of obstetric bleeding in a timely manner may improve obstetric prognoses. Postpartum hemorrhage was the leading cause of DIC associated organ failure in obstetrics admitted to the ICU. DIC and amniotic fluid embolism were independent risk factors for organ failure in patients admitted to the ICU. Postpartum hemorrhage was the leading disease associated with DIC (71, 81.6%), followed by hypertensive disorders (27, 31.0%), sepsis (15, 17.2%), acute fatty liver of pregnancy (11, 12.6%) and amniotic fluid embolism (10, 11.5%). Among 297 ICU admissions (median Sequential Organ Failure Assessment score, 4) for obstetric diseases, there were 87 DIC cases, with an estimated DIC incidence of 87 per 87,580 deliveries. The durations of hospital stay and ICU stay were recorded as secondary outcomes. The maternal outcomes included the changes in organ function 24 h after ICU admission. The diagnosis of DIC was confirmed by an International Society of Thrombosis and Hemostasis score greater than or equal to 5. doi:10.4103/0970-9185.We aimed to determine disseminated intravascular coagulation (DIC)-associated organ failure and underlying diseases based on data from three ICU wards in tertiary hospitals in China from 2008 to 2016. Amniotic fluid embolism: an interdisciplinary challenge: epidemiology, diagnosis and treatment. Amniotic fluid embolism: an evidence-based review. Rudra A, Chatterjee S, Sengupta S, Nandi B, Mitra J. Amniotic fluid embolism syndrome: analysis of the United States International Registry. Amniotic Fluid Embolism (Anaphylactic Syndrome of Pregnancy).Ĭonnecticut State Department of Public Health. What is Amniotic Fluid Embolism?Ĭleveland Clinic.
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